• Almost all DHEA is produced by adrenal glands in Zona reticularis is adrenal cortex. Other sites are Gonads and Brain.
  • DHEA secretion is approximately 30 mg/day in young men under sedentary condition and in Women: 20mg/day.
  • Secretion increases in strenuous physical activities and stressful conditions.
  • DHEA level decreases with aging.
  • Emotional Stress increases DHEA level temporarily.
  • High Protein and Saturated fat diet increase DHEA level.
  • Sugar, Sweets, Cereals rich in fibre such as whole grain bread, and bran flakes reduce DHEA levels.
  • DHEA's main actions are through conversion into more potent hormones.
  • Through these hormones DHEA expresses typical Male and Female hormone activity, as well as enhances the immune system.
  • One of the way it reinforces immunity is by converting into the very immune enhancing Androstenediol and Androstenetriol.
  • DHEA appears to have actions of its own, probably through DHEA receptors in target cells, particularly endothelial cells of blood vessels and immune cells as suggested in several studies.
  • It is believed that DHEA boosts the immune system and protects blood vessels against atherosclerosis partially by binding these receptors.

Indications For DHEA Replacement Therapy

  • Androgen Replacement Therapy
  • Subclinical Addison's disease
  • Adrenal Fatigue
  • Aging
  • Chronic Inflammation
  • Sexual Dysfunction
  • Mood disorders
  • SLE
  • Component of Menopause HRT
  • Component of Andropause HRT
  • Component of Somatopause HRT
  • Osteoporosis
  • Skin Pigmentation
  • Polymyalgia Rheumatica
  • Generalized arousal disorder in women
  • Since 2000, DHEA supplementation has been used in reproductive medicines in combination with Gonadotropins as a way to treat female Infertility.

Questionnaires

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