• The majority of GH is produced during the first 3-4 hours of the sleep by the Pituitary Gland.
  • GH production peaks in adolescence, reaching about 1500 mcg/day.
  • In well developed young men and women at age 25, production averages about 350 mcg per day.
  • By far, the highest GH levels in the blood are found during the first 3-4 hours of sleep at night in men and in early morning in women.
  • GH levels decrease with aging but Pituitary gland retains its ability to release Growth hormone when stimulated.
  • Insulin Like Growth Factor-1 (IGF-1) is a hormone produced by Liver under stimulation of GH and intake of food, particularly proteins.
  • IGF-1 mediates and thus produces a large part, but not all, of GH's effects.
  • Measuring serum IGF-1 levels is a good marker GH activity because it has more stable blood levels than GH during daytime.
  • GH is a major anabolic hormone that powerfully builds the body and is responsible for a great part of the growth that takes place during childhood and puberty.
  • GH increases the size and volume of brain, skin, muscles, bones and internal organs.
  • In adults, GH substantially helps to maintain the appropriate volume and tone of the skin, muscle and bone.
  • GH maintains a normal body composition by increasing nitrogen retention and stimulation of skeletal muscle growth, and by mobilizing of body fat.
  • Subcutaneous and Visceral adipose tissues are responsive to GH.
  • In addition to enhanced lipolysis, GH decreases the uptake of triglycerides into the body fat stores.
  • GH is a hyperglycaemic hormone.
  • A decrease in GH production causes an acceleration of aging process, with atrophy and sagging of skin, muscles and tissues. The wrinkles and fat begin to replace the smooth skin and muscles.
  • GH increases the function, repair and health of muscles, heart, lungs, liver, kidneys, joints, nerves and the brain.
  • GH's mental and emotional impact is substantial because GH stimulates the parasympathetic nerves, which contain many mood calming neurons.

Indications For Growth Hormone Replacement Therapy

  • Insufficient secretion of GH.
  • Adult Growth hormone deficiency.
  • Turner Syndrome.
  • Chronic Renal Insufficiency.
  • Prader Willi Syndrome.
  • Idiopathic Short Stature.
  • Somatopause.
  • Component of Andropause HRT.
  • Component of Menopause HRT.
  • Component of Adrenopause HRT.
  • Age related Cognitive decline.
  • Age related muscle atrophy.
  • Skin Aging.
  • Obesity.
  • Osteoporosis.
  • Improvement of body composition and muscle strength.
  • Cachexia.
  • Infertility (Induction of ovulation ; used along with Gonadotrophins)

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