• Daily secretion of Progesterone is 1-2 mg per day in the first half (follicular phase) of the menstrual cycle where it is almost entirely produced by adrenal glands and 20-40 mg per day in the second phase (luteal phase) of the menstrual cycle due to ovarian production.
  • In men, progesterone production apparently amounts to be 1.5-3.0 mg per day and is almost entirely by the adrenal glands.
  • Intensive prolonged physical activity, such as sexual intercourse and long distance running, use up the sex hormones and may thereby reduce the levels of female hormones.
  • Intense emotional stress can inhibit the secretion of Progesterone.
  • High protein and/or saturated fat intake increases Progesterone production.
  • Eating sugar and fibres can reduce female sex hormone levels.
  • Women are born with 1-2 million undeveloped eggs in their ovaries. When women reach puberty and start menstruating , only about 300,000 immature egg cells, or follicles remain, of which an average 600 egg cels die per month and are not replaced.
  • No good egg remains at the time of menopause and since the eggs are the principal producers of female hormones, this explains why all women become hormone deficient over time.
  • Progesterone acts as a diuretic and prevents the fluid retention caused by estrogens.
  • Progesterone's role is to prepare the uterus for implantation of fertilized egg cell.
  • Progesterone closes the uterine cervix during the luteal phase and pregnancy.
  • Progesterone relaxes the smoth muscles of uterus, GIT and blood vessels.
  • Progesterone thickens the cervical mucus and dries vaginal secretions.
  • Progesterone calms down the emotions and mood by stimulating the parasympathetic nervous system.
  • Progesterone promotes Bone and Brain health.
  • Progesterone has some anti-androgen properties also.
  • Progesterone has some aldosterone blocking properties also.

Indications For Progesterone Replacement Therapy

  • Progesterone deficiency states.
  • Primary ovarian failure.
  • Hypogonadism
  • Menopausal HRT
  • PCOD
  • Habitual abortions
  • Luteal phase defect
  • Pre Menstrual Syndrome
  • Menstrual irregularities
  • Menorrhagia
  • Macromastia
  • Hirsutism
  • Endometrial hyperplasia
  • Dysfunctional uterine bleeding
  • Infertility
  • Breasts cysts
  • Fibroadenoma
  • Uterine fibroids
  • Hirsutism
  • Acne
  • Osteoporosis
  • Fibromyalgia
  • Polymyalgia Rheumatica
  • Benign Prostatic Hyperplasia
  • Prostatic Carcinoma

Questionnaires

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